DLBCL awareness
نویسندگان
چکیده
منابع مشابه
Ontogenesis of Dlbcl
Diffuse Large B-Cell Lymphomas (DLBCLs) are the most common histologic subtype within non-Hodgkin’s lymphomas (NHLs), accounting for approximately 30% of them. These lymphomas are a heterogeneous clinicopathologic entity characterized by marked phenotypic and clinical differences and several data indeed suggest that under the name of DLBCL different disease entities are currently included. This...
متن کاملCNS involvement in DLBCL.
A 70-year-old woman presented with 4 weeks of progressive bilateral lower extremity weakness. She had past medical history of stage III diffuse large B-cell lymphoma treated with 6 cycles of R-CHOP chemotherapy, which was completed 6 months prior to presentation. All risk factors for central nervous system (CNS) relapse were negative except for thickening of left paranasal sinus. A computed tom...
متن کاملCheck'-ing DLBCL
MYC is a potent oncogene that encodes a transcription factor which regulates a plethora of target genes related to cell growth and cell cycle. Not surprisingly, a vast majority of human cancers are characterized by high constitutive Myc levels promoting oncogenesis. In particular, in mature B-cell neoplasms Myc overexpression is often associated with an aggressive clinical behavior. Interesting...
متن کاملCell-specific PD-L1 expression in DLBCL.
In this issue of Blood, a new study by Kiyasu et al used a double-staining technique to identify cell-specific programmed cell death ligand 1 (PD-L1) expression in 1253 diffuse large B-cell lymphoma (DLBCL) samples and analyzed the findings together with programmed death-1 (PD-1) expression in tumorinfiltrating lymphocytes (TILs) and clinical outcomes, providing new insights into the role of th...
متن کاملAttacking MALT1 for ABC-DLBCL therapy
Diffuse large B-cell lymphoma (DLBCL) comprises the largest group of non-Hodgkin lymphoma (NHL). DLBCL can be classified according to their cellular origin and patients with the activated B-cell (ABC) subtype have an inferior prognosis relative to those with the germinal center B-cell (GCB) subtype. Constitutive anti-apoptotic NF-κB signaling is a hallmark of ABC-DLBCL. NF-κB activation is caus...
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ژورنال
عنوان ژورنال: British Dental Journal
سال: 2011
ISSN: 0007-0610,1476-5373
DOI: 10.1038/sj.bdj.2011.728